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The ability to link pain cohorts to multi-dimensional routine health and non-health related datasets UK-wide. start looking for painkillers and therapies specifically designed for visceral pain, which although they are desperately needed do not currently exist. the data sets to be included within the hub, describing the data sets that will be brought together under the APDP initiative and linked to the HDR UK Alliance over the course of the award and include the data custodians, modes and sizes of datasets (number of records, populations covered), the current quality of the data (coverage, completeness, validity, timeliness and accuracy) and the environment in which they are currently stored (process and governance for access) Consortium Against Pain in Equality (CAPE) – The impact of adverse childhood experiences on chronic pain and responses to treatment

the physical environment the partnership will provide as a hub base to support collaboration and innovations across a range of users (for example data scientists, clinicians) from industry, the NHS and academia Organisations are encouraged to use and build on existing infrastructure and assets (for example, Safe Havens) where appropriate. The funding will not support building work or other significant capital expenditure. Pain that lasts a long time (is chronic) takes apart lives, relationships and families. Although biological signals can help understand why pain happens, they do not fully account for the experiences people have, or why pain develops the way it does. Psychological and social factors, such as thoughts and feelings, personal relationships, and lifestyle, can also affect chronic pain. However, we do not yet know which of these psychological and social mechanisms are most important, or how they combine with biological signals to affect chronic pain.The hub will be part of the UKRI and Versus Arthritis Strategic Priority Fund (SPF) Advanced Pain Discovery Platform. It will underpin original research by providing innovative new data assets for pain research in areas of need. It will not support original research directly. The hub will adopt the HDR UK brand, offering a trustworthy approach for the public that is recognised by industry and at a national level in policy development. Partnership with other hubs in the network will also be facilitated, providing opportunities to share best practice and deliver collaborative projects. About HDR UK – UK Health Data Research Alliance and Innovation Gateway Read a full account of grant costs. Please note that this hub investment will not support direct research activities into pain. leading academics in pain research covering the range of data modalities across biological, psychological and social factors that influence pain. Our Co-I’s are leading applicants in 4 separate APDP consortia bids

The case for support forms the main body of your proposal and should contain the following sections: On Reddit, examples of this can be found on a routine basis. Many "pain hub" accounts, which post "painful" content made to invoke sadness, have also taken advantage of the term. The newly-established Pain Research Data Hub will be expected to work collaboratively with the other Health Data Research Hubs in a single UK-wide network and with other components of the relevant national health data landscape. Supporting documents We will also examine differences between men and women, why certain conditions predominantly affect women, and the under-representation of women in some research areas, to make sure that any new treatments benefit everyone equally.your plan for sustainability of the hub (through, for example, a robust portfolio of grant funding, service charges, commercial funding) while continuing to adhere to the principles for participation and a commitment to open access of methodologies, code and findings. provide publishable enhanced service case studies (for example from industry, academia and the NHS) that demonstrate impact (and expected impact) and value to researchers and innovators from a range of sectors, and to people with pain and populations Be central to all data and results generated by all of the APDP research programmes, including the large consortia and hypothesis driven research projects. have strong leadership, deep domain expertise and governance, including plans for including people with pain and members of the public in decision-making and governance and how the hub will ensure that research outcomes from its work are linked to patient benefits

The UK Health Data Research Alliance was established in February 2019. The purpose of the Alliance is to bring together and facilitate partnership working across NHS organisations and other health data custodians, leading to an ethical, consistent approach to data provision and public engagement.

Consortium Against Pain in Equality (CAPE), led by Professor Tim Hales, University of Dundee, researching the impact of adverse childhood experiences on chronic pain and responses to treatment Health Data Research UK (HDR UK) was established in 2017 and is the national institute for health data science. It aims to unite the UK’s health data to enable discoveries that improve people’s lives. This call is for funding to establish the pain research data hub within HDR UK, providing complementarity activities to the existing portfolio of Health Data Research Hubs. Funding is available for the development of one hub over three years. We’ll cover 67% of the full economic costs.

provide evidence that public involvement is at the centre of the hub’s governance processes, that the hub is implementing its plan for meaningful public and patient involvement and demonstrate its effects on the hub’s activities. Our visceral pain database will enrol individuals with pain originating from the bladder, gut, lung, kidney, pancreas, uterus and vagina, and in the pelvis. It will be built on existing hospital and GP records and will be future-proof, set up to grow and recall volunteers for additional studies. We will also work closely with similar pain consortia being set up across the UK. We will optimise measures to assess NeuP, including sensory profiling, application of remote monitoring and assessment of psychosocial factors to understand the impact of pain on daily activities (from self-care to work) and important conditions that are often associated with chronic pain such as depression, anxiety and poor sleep. Our UK-wide consortium will deliver world class health data infrastructure and services for pain research, guided by leading experts in pain research and in partnership with the NHS, Advanced Pain Discovery Platform (APDP) consortia, people with lived experience of chronic pain (PWLE) and industry. This consortium has a common desire and a commitment for change to a “data as infrastructure” approach. Guided by leading experts in pain research in partnership with the NHS, APDP consortia, people with lived experience of chronic pain and industry, Alleviate will:

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UKRI, Versus Arthritis and Eli Lilly invited proposals to establish a pain research data hub in partnership with Health Data Research UK. The purpose of the hub is to bring together and curate health data from the NHS, social care and research (academic and industry) to provide innovative new high value data resources for pain research and innovation. Chronic pain is a major unmet global public health challenge and can have a devastating effect on the lives of those it affects and those around them. It is estimated that up to 20% of the UK population suffer chronic pain. As a result, this also represents a major challenge for the UK economy. quality of the plans for meaningful patient and public involvement throughout the award, including plans to allow access to data