Liposomal Luteolin Capsules 500mg, Maximum Absorption, High Dose Flavonoid, Antioxidant Supplement, Soy-Free, Glute-Free, Non-GMO

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They are meant to complement a healthy lifestyle and should be used as part of an overall approach to wellness. Jiang ZQ, Li MH, Qin YM, Jiang HY, Zhang X, Wu MH. Luteolin Inhibits Tumorigenesis and Induces Apoptosis of Non-Small Cell Lung Cancer Cells via Regulation of MicroRNA-34a-5p. Int J Mol Sci. 2018;19(2):447. Allergic reactions: Some individuals may be allergic to luteolin or other ingredients present in the supplement. This can manifest as itching, rash, hives, swelling, or difficulty breathing. If you experience any allergic reactions, discontinue use and seek medical attention immediately. As a result, it is not surprising that luteolin supplements are becoming increasingly popular among adults seeking to maintain their health and vitality as they age. Onset of redox stress resulting in the cascade of several deleterious biochemical and physiological events marks the commencement of oncogenesis. It mainly arises from the generation of a diverse group of highly reactive, oxygen containing species with a short lifespan that serve as second messengers for cellular signaling. These include hydrogen peroxide (H 2O 2), hydroxyl radical (.OH), singlet oxygen ( 1O 2), superoxide radical (O 2 -), and lipid peroxyl radical (LOO). The reactive oxygen species (ROS) are known to manifest irreparable damage to DNA, proteins, and lipids. that eventually causes diseases including cancer.

Cantu-Medellin N, Kelley EE. Xanthine oxidoreductase-catalyzed reactive species generation: a process in critical need of reevaluation. Redox Biol. 2013;1(1):353–8. Aromokeye R, Si H. Combined Curcumin and Luteolin synergistically inhibit Colon Cancer Associated with Notch1 and TGF-β signaling pathways in cultured cells and xenograft mice. Cancers. 2022;14(12):3001. Yan M, Liu Z, Yang H, Li C, Chen H, Liu Y, Zhao M, Zhu Y. Luteolin decreases the UVA–induced autophagy of human skin fibroblasts by scavenging ROS. Mol Med Rep. 2016;14(3):1986–92.In the plants, the flavonoid often stays in the glycosylated form. However, when humans use them, the glycoside is hydrolyzed, which results in freeing the Luteolin, thus helping in the absorption process. What makes this flavonoid unique is that it is heat stable. Although the above seven foods are wonderful sources of luteolin, they're far from the only ones out there. Researchers ranked the top sources of luteolin: They found that radicchio took the lead (by a landslide). However, trailing closely behind were other ingredients like serrano pepper, red leaf lettuce, artichoke, spinach, and broccoli. And although there aren't many luteolin-rich fruits, lemons contain a considerable amount of the flavonoid—nearly as much as celery and chicory greens. That said, there are other fruits with a smaller amount of luteolin, including watermelon, cantaloupe, navel oranges, grapefruit, kiwi, and blueberries. Scientists are exploiting these properties extensively to make the chemical beneficial for humans. In humans, flavonoids have shown multiple advantages like acting as antioxidants, antimicrobial agents, and estrogenic regulators.

Sun DW, Zhang HD, Mao L, Mao CF, Chen W, Cui M, Ma R, Cao HX, Jing CW, Wang Z, et al. Luteolin inhibits breast Cancer Development and Progression in Vitro and in vivo by suppressing Notch Signaling and regulating MiRNAs. Cell Physiol Biochem. 2015;37(5):1693–711. Cancer claims a towering morbidity and mortality rate worldwide. As per the report published by World Health Organization on 3 February 2022, cancer is the leading cause of death around the globe with 10 million total deaths alone in the year 2020 due to lung cancer (1.80 million deaths of 2.21 million cases), colon cancer (0.91 million deaths of 1.93 million cases), and breast cancer (0.68 million deaths of 2.26 million cases) ( https://www.who.int/news-room/fact-sheets/detail/cancer). Chemotherapy has served as a silver lining to the cancer patients; however, the side effects and a sizeable mortality rate demands alternative treatment regime with physiologically safe drugs to which the naturally occurring compounds present a robust candidature. Furthermore, the evolution of drug resistance in cancer cells aggravates the need for safer alternatives with optimal efficacy for sensitizing the cancer cells towards conventional drugs [ 1].However, it’s important to note that the research on luteolin’s specific side effects is limited, and individual responses may vary. Cyclin-dependent kinases (CDK)-cyclin complexes regulate the cell cycle responsible for cell growth, development, and differentiation. The dysregulation of cell cycle transforms normal cells to tumor cells. Considering its association towards the development of tumorigenesis, the chemical agents that arrest cell cycle progression have drawn a considerable attention towards the development of anticancer therapeutics [ 19].

Zhang Q, Yang J, Wang J. Modulatory effect of luteolin on redox homeostasis and inflammatory cytokines in a mouse model of liver cancer. Oncol Lett. 2016;12(6):4767–72. Raj Rai S, Bhattacharyya C, Sarkar A, Chakraborty S, Sircar E, Dutta S, Sengupta R. Glutathione: role in Oxidative/Nitrosative stress, antioxidant defense, and treatments. ChemistrySelect. 2021;6(18):4566–90. EGF receptor (EGFR) is a typical receptor protein tyrosine kinase (PTK) that mediates cell growth and proliferation. When activated by its ligands, EGFR is phosphorylated to mediate activation of downstream signaling pathways, including MAPK and PI3K/Akt [ 88]. Luteolin was found to inhibit the proliferation of pancreatic and prostate cancer and human epidermoid carcinoma cells, which is closely associated with the inhibition of the PTK activity and autophosphorylation of EGFR, transphosphorylation of EGFR downstream effector protein enolase, and activation of MAPK/ERK [ 89]. Zhou YS, Cui Y, Zheng JX, Quan YQ, Wu SX, Xu H, Han Y. Luteolin relieves lung cancer-induced bone pain by inhibiting NLRP3 inflammasomes and glial activation in the spinal dorsal horn in mice. Phytomedicine. 2022;96:153910. Gao G, Ge R, Li Y, Liu S. Luteolin exhibits anti-breast cancer property through up-regulating miR-203. Artif Cells Nanomed Biotechnol. 2019;47(1):3265–71.A cell line study suggests that luteolin (and quercetin) “display progesterone antagonist activity beneficial in a breast cancer model but deleterious in an endometrial cancer model.” However, this is just a cell line study, and it only suggests caution with consuming luteolin via supplement, not from a plant-rich diet. While I’m familiar with chicory thanks to New Orleans–style coffee (which involves roasting, grinding, and brewing the root of the plant), Dr. Naidoo says that their greens can be incorporated into meals similar to other leafy greens. However, she cautions that they have a robust flavor profile, so she offers a few tips to enjoy them without overwhelming your palate. “I recommend adding chicory greens to soups or stews, or sautéing them in avocado oil for a flavorful side dish,” she advises. 5. Celery The mechanism of inhibition of cell cycle and pro-apoptotic effect of luteolin on human non-small-cell lung carcinoma cell lines A549 was analyzed by Cai et al. [ 23]. The flow cytometry investigations have revealed increased number of apoptotic cells and G2 phase cells indicating the non-progression of cells beyond G2 phase. The western blot assay indicated the activation of JNK by luteolin, augmented the production of Bax, and increased cleavage of procaspase-9 and caspase-3. The pretreatment of A549 cells with luteolin led to an inhibition of TNFα-mediated trans-nuclear translocation of NF-kB. There are multiple ways in which Luteolin works and hence are exploited extensively by researchers.

Luteolin is consumed through various sources like fruits or vegetables, and it converts to glucuronides when the food passes down the intestinal mucosa. This conversion is required to make the absorption process more efficient. How does it work: Nazim UM, Park SY. Luteolin sensitizes human liver cancer cells to TRAIL–induced apoptosis via autophagy and JNK–mediated death receptor 5 upregulation. Int J Oncol. 2019;54(2):665–72. Luteolin treatment reportedly increased the number of intracellular autophagosomes, as indicated by an increased expression of Beclin 1, and conversion of LC3B-I to LC3B-II in hepatocellular carcinoma SMMC-7721 cells. These events suggest the onset of autophagy in cancer cells followed by their exposure to luteolin which was validated by a reduction in luteolin-induced autophagy in the presence of autophagy inhibitor chloroquine. However, the effect of autophagy was only partial as cell cycle arrest and induction of apoptosis were also noticed as contributing factors [ 31]. Flavonoids are believed to have health-promoting effects, and luteolin is no exception. This compound has been shown to possess antioxidant, anti-inflammatory, and neuroprotective properties.After reading the names of the sources, it might seem that these are present in our daily diet. But here’s the thing, even though Luteolin’s source is quite common, we tend to get as less as 1mg per day, even with a typical diet. Introduction Tan X, Yang Y, Xu J, Zhang P, Deng R, Mao Y, He J, Chen Y, Zhang Y, Ding J, et al. Luteolin exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 pathway in Intracerebral Hemorrhage. Front Pharmacol. 2019;10:1551.