Terumo Syringe 2.5ml Luer Lock Syringe, Pack of 100

Product Information

The half-life of timolol in plasma is about 6 hours. Timolol is extensively metabolised in the liver. Latanoprost eye drops may gradually change eye colour by increasing the amount of brown pigment in the iris. Before treatment is instituted, patients should be informed of the possibility of a permanent change in eye colour. Unilateral treatment can result in permanent heterochromia. Signs and symptoms of CNS toxicity (convulsions, circumoral paresthesia, numbness of the tongue, hyperacusis, blurred vision, unconsciousness, tremor, light headedness, tinnitus, dysarthria). All indications: Adults: The recommended dose may be increased or decreased. Doses above 80 mg/day have not been systematically evaluated. Choroidal detachment has been reported with administration of aqueous suppressant therapy (e.g. timolol, acetazolamide) after filtration procedures.

The dose of 5 micrograms/kg/day (approximately 100 times the clinical dose) caused significant embryofoetal toxicity characterised by increased incidence of late resorption and abortion and by reduced foetal weight. Studies in man indicate that the peak concentration in the aqueous humour is reached about two hours after topical administration. After topical application in monkeys, latanoprost is distributed primarily in the anterior segment, the conjunctivae and the eyelids. Only minute quantities of the drug reach the posterior segment. Studies in animals and man indicate that the main mechanism of action is increased uveoscleral outflow, although some increase in outflow facility (decrease in outflow resistance) has been reported in man. Studies in man indicate that the maximum concentration in the aqueous humour, approximately 15-30 ng/ml, is reached about 2 hours after topical administration of latanoprost alone. After topical application in monkeys latanoprost is distributed primarily in the anterior segment, the conjunctiva and the eye lids.Milligrams (mg) are units of weight, while millilitres (ml) are liquid volume units. The word ‘Milli’ is derived from the Latin mille, which signifies a thousand. A gram has 1,000 milligrams, while a litre of the liquid has 1,000 millilitres. An alternative is also that one milliliter is approximately zero times two point five liters. Conversion table liters to milliliters chart

A milligram is one thousandth of a kilogram, while a milliliter is one thousandth of a liter. Take note of the additional thousandth on the weight unit. As a result, a milliliter must contain 1,000 milligrams, yielding the following formula for mg to ml conversion: Accumulation of pigment in the trabecular meshwork or elsewhere in the anterior chamber has not been observed but patients should be examined regularly and, depending on the clinical situation, treatment may be stopped if increased iris pigmentation ensues. Bupivacaine is contra-indicated in patients with hypersensitivity to bupivacaine hydrochloride monohydrate, local anaesthetic agents of the amide type or to any of the other excipients listed in section 6.1.Adverse events are categorised by frequency as follows: very common (≥ 1/10), common (≥ 1/100 to <1/10), uncommon (≥ 1/1,000 to <1/100), rare (≥ 1/10,000 to < 1/1,000) and very rare (<1/10,000) We can also convert by utilizing the inverse value of the conversion factor. In this case 1 milliliter is equal to 0.013525609023568 × 2.5 fluid ounces. No further increase in brown pigment has been observed after discontinuation of treatment, but the resultant colour change may be permanent. The metric system is a measuring system that replaced the decimalized system based on the metre that was launched in France in the 1790s. The historical evolution of these systems culminated in establishing the International System of Units (SI), which an international standards organization oversaw. Before treatment is instituted patients should be informed of the possibility of a change in eye colour. Unilateral treatment can result in permanent heterochromia.

Latanoprost (MW 432.58) is an isopropyl ester prodrug which per se is inactive, but after hydrolysis to the acid of latanoprost becomes biologically active. We can also convert by utilizing the inverse value of the conversion factor. In this case 1 teaspoon is equal to 1.971568645832 × 2.5 milliliters. The colour change is due to increased melanin content in the stromal melanocytes of the iris and not to an increase in number of melanocytes. Typically, the brown pigmentation around the pupil spreads concentrically towards the periphery in affected eyes, but the entire iris or parts of it may become more brownish. No further increase in brown iris pigment has been observed after discontinuation of treatment. It has not been associated with any symptom or pathological changes in clinical trials to date. Systemic toxic reactions primarily involve the central nervous system (CNS) and the cardiovascular system. Such reactions are caused by high blood concentrations of a local anaesthetic, which may appear due to (accidental) intravascular injection, overdose or exceptionally rapid absorption from highly vascularised areas (see section 4.4). CNS reactions are similar for all amide local anaesthetics, while cardiac reactions are more dependent on the medicinal product, both quantitatively and qualitatively. Signs of toxicity in the central nervous system generally precede cardiovascular toxic effects, unless the patient is receiving a general anaesthetic or is heavily sedated with medicinal products such as benzodiazepine or barbiturate. There is practically no metabolism of the acid of latanoprost in the eye. The main metabolism occurs in the liver. The half-life in plasma is 17 minutes in man. The main metabolites, the 1,2-dinor and 1,2,3,4-tetranor metabolites, exert no or only weak biological activity in animal studies and are excreted primarily in the urine.Antidepressants should be used with caution in patients with a history of mania/hypomania. As with all antidepressants, fluoxetine should be discontinued in any patient entering a manic phase. As a result, the weight in milliliters equals milligrams divided by 1,000 times the density of the substance or material.

In paediatric trials, mania and hypomania were commonly reported (see section 4.8). Therefore, regular monitoring for the occurrence of mania/hypomania is recommended. Fluoxetine should be discontinued in any patient entering a manic phase. Like all local anaesthetic medicinal products, bupivacaine may cause acute toxicity effects on the central nervous and cardiovascular systems if utilised for local anaesthetic procedures resulting in high blood concentrations of the medicinal product. This is especially the case after unintentional intravascular administration. Ventricular arrhythmia, ventricular fibrillation, sudden cardiovascular collapse and death have been reported in connection with high systemic concentrations of bupivacaine.

Pivotal studies have demonstrated that latanoprost is effective as monotherapy. In addition, clinical trials investigating combination use have been performed. These include studies that show that latanoprost is effective in combination with beta-adrenergic antagonists (timolol). Short-term (1 or 2 weeks) studies suggest that the effect of latanoprost is additive in combination with adrenergic agonists (dipivalyl epinephrine), oral carbonic anhydrase inhibitors (acetazolamide) and at least partly additive with cholinergic agonists (pilocarpine). Latanoprost / Timolol 50 micrograms / ml + 5 mg / ml Eye Drops, Solution should be used with caution, in patients with mild/moderate chronic obstructive pulmonary disease (COPD) and only if the potential benefit outweighs the potential risk.